This study aimed to evaluate the clinical, haematobiochemical and histopathological changes in goats
with surgically induced unilateral hydronephrosis. To achieve this aim eight male castrated goats were
divided into two groups. Group A (animals with surgically-induced unilateral hydronephrosis) in which
goats were subjected to ligation of the right ureter for 42 days and group B (sham-operated). Clinical
examination and haematobiochemical analysis were performed before and after induction (on days 1, 7,
14, 21, 28, 35 and 42). Histopathological examination of kidneys was carried out at the end of the study.
On the 1st day goats with unilateral hydronephrosis showed depression, arched back, decreased appetite.
After that, these clinical signs were ameliorated and the animals restored their apparent health condition.
PCV%, Hb content and RBCs count increased during the early periods of the study then returned
gradually to normal level by the end of the study. WBCs count was significantly increased allover the
time of the study. Significant increase of serum urea, creatinine, uric acid and calcium levels during the
early period of the study then gradually decrease. Albumin and total proteins levels were initially
decreased but were restored by the end of the experiment. Post-mortem examination of affected kidneys
showed dilatation of renal pelvis and calyces with severe atrophy of the parenchyma. Histopathological
examination of affected kidneys revealed severe cystic dilatation of renal tubules and intertubular
connective tissue proliferation. We concluded that unilateral hydronephrosis produced significant
changes during the early stage, which were gradually restored owing to the compensatory activities of
the contralateral kidney.