Background: The oil and natural gas sector has a significant place in the world’s economy. It increasesthe risk of work related fatality, injury and diseases. The aim: of the present study was to assess occupational health hazards and exposure indicators among onshore drilling workers. Design: A descriptive design was used. Setting and Sample: Convenience sample of drilling workers were selected under the inclusion criteria (60 workers). The study was done in Egyptian drilling company in Kalbasha, MarsaMatrooh. Tools:an interviewing questionnaire developed by the researcher to assess characteristics of workers,awareness of workers about health hazards found in their work place, the exposure indicators to occupational health hazards, awareness of workers about hazard control measures used in their company, and the level of workers' acceptance to health and safety activities applied in the company. The main results of the present study: It showed that all studied workers reported chemical hazard one of the occupational health hazards found in their company, and 83.3% of them mentioned physical hazards, followed by ergonomic hazards 58.3% and psychosocial hazards 45.0%. Conclusion: About one third of studied workers suffered from health problems related to exposure to occupational hazards in their work; they suffered from dermal, respiratory and musculoskeletal problems. Recommendation: Effective health education programs and obligatory free training about hazards and safety measures should be provided to the workers.