The goal of treatment in patients with chronic hepatitis C virus (HCV) infection is to eradicate hepatitis C virus (HCV) RNA, the predictors for the patients that underwent interferon therapy is crucial. This is retrospective study carried on 50 patients (40 males, 10 non pregnant females). The patients divided into 2 groups, (1) responder (29 males, 8 females). Mean age (50.5  4.53 years old) and group (2) non responder (11 males, 2 females). Mean age (48.6  6.37 years old). The results of the investigations between responders and non responders was of no statistical significant, P value > 0.05 for all including iron indices (serum ferritin, serum iron and total iron binding capacity). There was statistical significant difference for T4,PCR viral load and INR, p value < 0.05. Serum ferritin cut-off level 19.25um/l, with sensitivity 75.7% and specificity 38.5% and Coefficient interval (CI 0.42 - 0.8) by ROC Curve, p value > 0.05 and that was not statistically significant. Conclusion, patients with chronic HCV need more care for the prediction to the therapy to avoid the side effects as well as the economic cost. Serum ferritin level has no role to the prediction of therapy in this study. Recommendation for further study to prove or disprove this issue .