To investigate the relationship between clinical parameters of pre-eclampsia (PE) and serum levels of Retinol binding protein4 (RBP4) and Placental growth factor (PlGF). Patients and Methods: The study included 90 pregnant women categorized as Group I: Control group (n= 20), included pregnant women who continued their pregnancy without development of PE manifestations, Group II: included patients had Mild PE (n=56) and group III included patients had Severe PE (n=14). After clinical evaluation and ultrasonographic examination, samples ofmaternal peripheral blood were obtained either at time of diagnosis of PE in groups II and III or at time of delivery in control group for ELISA estimation of serum RBP4 and PlGF. Results: PE patients had significantly lower serum PlGF, but significantly higher serum RBP4 levels when compared to the corresponding levels of the control group. Serum levels of PlGF showed negative correlation with systolic and diastolic blood pressures (SBP and DBP) and extent of proteinuria, but showed positive significant correlation with birth weight, while serum levels of RBP4 showed positive significant correlation with DBP, extent of proteinuria and patients' body weight measures. Conclusions: RBP4 and PlGF were associated with the development and severity of PE. [Adel F. Al-Kholy, Mamdouh Z. Abadier, Ebrahem M. Rageh, Hany El-Kallaf.Serum levels of placental growth factor and retinol-binding protein-4 in pregnancy-induced hypertensive women. Journal of American Science 2010;6(12):448-455]. (ISSN: 1545-1003).