Hypertension is a crucial risk factor for cardiovascular diseases. Diuretic drugs are frequently used to reduce blood pressure, even though many possess harmful and undesirable side effects. Therefore, the use of alternative treatments such as medicinal plants are considered a good strategy to treat hypertension and its related diseases. Fortunately, many efforts have been made to verify the efficiency of traditional medicinal plants such as the black seed Nigella sativa (Ranunculaceae) in benefit of health. Its seeds exhibit a wide variety of pharmacological actions to control diabetes, hypertension, cancer, inflammation, hepatic disorder, arthritis, kidney disorder, and cardiovascular complications. Several mechanisms have been proposed in the literature to explain the effect of N. sativa supplementation on lowering blood pressure levels. In this chapter, we discuss in detail the pharmacology, and phytochemical composition of N. sativa that acts in prevention, management, and treatment of hypertension.