Pregnancy is a special physiological state where medication intake presents a challenge and concern due to altered drug pharmacokinetics and drug crossing the placenta possibly causing harm to the fetus. Aim: The aim of this study was to investigate the effectiveness of video assisted nursing counseling intervention on pregnant women knowledge, attitude and practice towards self -medication. Design: Quasi - experimental design (pre-post counseling) was used to carry out the study. Setting: The study was conducted in two Maternal and Child Health Care Centers at Shebin Elkom, Menoufia governerate. Sampling: A purposive sample of two hundred and fifty-seven pregnant women (one group pretest and posttest). Tools: Four tools were used for data collection a) Interviewing questionnaire b) Knowledge assessment questionnaire c) Attitude assessment questionnaire d) Practice assessment questionnaire. Results: This study showed that there was a highly significant difference at study participants knowledge, attitude, and practice towards self-medication pre and post video assisted nursing counseling intervention. Conclusion: Video assisted nursing counseling intervention had high significant impact on improving knowledge, changing attitude, and practice of study participants towards self-medication. Recommendation: ongoing education for maternity nurses about self-medication during pregnancy and its bad consequences, implementing in-service counseling programs regarding side effect of self- medication use during pregnancy to all expectant women, and replication of the study with large sample size to further settings.