Background/Aim: Aluminum chloride is one of the most common causative factors in many neurodegenerative disorders. The present study aim to evaluation the effect of green tea and omega-3 on aluminum chloride induced neurotoxicity in rabbits. Materials and methods: Twenty four male rabbits were divided in to four groups. Control group, aluminum chloride group: rabbits were given aluminum chloride at a dose of 300mg/kg/day orally for one month. Green tea-treated group: rabbits were given aluminum chloride plus green tea extract at a dose of 50 mg/Kg/day orally for one month. Omega 3-treated group: rabbits were given aluminum chloride plusomega-3 at a dose of 20 mg/kg /day orally for one month. Then the brain tissues were examined for histopathological and immunohistochemical changes. Results: Aluminum chloride induced distortion in histological structures of dentate gyrus with significant increase in caspase-3 antibody reaction compared with control group indicating neuronal cell apoptosis. Green tea and omega 3 reduced the neurotoxin effect of aluminum chloride. However, omega 3 administration induced more improvement in aluminum chloride neurotoxicity than green tea. Conclusion: Omega 3 administration diminishes the neurotoxin effect of aluminum chloride on dentate gyrus more than green tea.