Staff Members - Benha University
Comparative study between intralesional injection of bleomycin and 5-fluorouracil in the treatment of keloids and hypertrophic scars
• 2016
Publication Information
Authors
Ahmed M. Kabel a,b,⇑
, Hanan H. Sabry c, Neveen E. Sorour c, Fatma M. Moharm
Keywords
Bleomycin; Fluorouracil; Keloids; Hypertrophic scars
Journal
Not Available
Publisher
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Volume
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Issue
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Pages
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publication.type
International
Paper Link
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Supplementary Materials
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Abstract
The aim of this work was to evaluate the efficacy and safety of intralesional injection of 5-fluorouracil and bleomycin in the treatment
of keloids and hypertrophic scars. One hundred and twenty patients were divided into the following groups: group IA was injected
intralesionally with 5-fluorouracil; group IB was injected intralesionally with a combination of triamcinolone acetonide and
5-fluorouracil; group II was injected intralesionally with bleomycin. Patients underwent follow up by photographing and Vancouver scar
scale system. There was a significant improvement in the Vancouver scar scale in group II compared to group I after treatment. There
was hyperpigmentation, pain and ulceration in all the studied groups. Pain was significantly decreased in group IB compared to that in
group IA, ulceration was significantly decreased in group II than in group I while pain after injection was increased in group II than in
group I. Relapse occurred in 12 patients of group IA, 14 patients of group IB and no relapse occurred in group II. So, intralesional
injection of bleomycin was more effective and better in remission than intralesional 5-fluorouracil injection in the treatment of keloids
and hypertrophic scars regardless of patient’s age, sex, disease duration or site of the lesion.
2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the
CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
of keloids and hypertrophic scars. One hundred and twenty patients were divided into the following groups: group IA was injected
intralesionally with 5-fluorouracil; group IB was injected intralesionally with a combination of triamcinolone acetonide and
5-fluorouracil; group II was injected intralesionally with bleomycin. Patients underwent follow up by photographing and Vancouver scar
scale system. There was a significant improvement in the Vancouver scar scale in group II compared to group I after treatment. There
was hyperpigmentation, pain and ulceration in all the studied groups. Pain was significantly decreased in group IB compared to that in
group IA, ulceration was significantly decreased in group II than in group I while pain after injection was increased in group II than in
group I. Relapse occurred in 12 patients of group IA, 14 patients of group IB and no relapse occurred in group II. So, intralesional
injection of bleomycin was more effective and better in remission than intralesional 5-fluorouracil injection in the treatment of keloids
and hypertrophic scars regardless of patient’s age, sex, disease duration or site of the lesion.
2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the
CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).