| publication name | Carbamazepine-Induced Hematological and Immunological Alterations in Egyptian Children with Idiopathic Generalized Seizures |
|---|---|
| Authors | Ola Samir El-Shimi Amina Ali Farag Amany Mohammed El-Rebigi Taghrid Gamaleldin Kharboush Hanaa El-Sayed Bayomy Rana Atef Khashaba |
| year | 2021 |
| keywords | Carbamazepine; immunological effects ; hematological effects; children; Egypt |
| journal | Journal of Child Science |
| volume | 11 |
| issue | 1 |
| pages | e265-e272 |
| publisher | Not Available |
| Local/International | International |
| Paper Link | https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0041-1736156.pdf |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
Carbamazepine (CBZ) is one of the oldest antiepileptic drugs (AEDs) that is still used for the treatment of tonic-clonic seizures in children. Long-term use of AEDs induces potential toxic effects that may remain undetermined for a long time. Earlier studies have revealed a wide spectrum of hematological toxicities associated with CBZ. This study was conducted to unveil the toxic effects of carbamazepine as an antiepileptic monotherapy on hematological and immunological parameters in a group of Egyptian pediatric patients using it for different durations. Fifty pediatric epileptics of either sex were enrolled; 38 were taking CBZ as antiepilepticmonotherapy for6months and 12 were newly diagnosed untreated patients. Hematological and immunological parameters studied were compared with their age and sex-matched 15 controls and among groups. CBZ was found more toxic for total leukocyte count, lymphocyte count, serum IgA and IgM levels (p