Staff Members - Benha University
Carbamazepine-Induced Hematological and Immunological Alterations in Egyptian Children with Idiopathic Generalized Seizures
Journal of Child Science • 2021
Publication Information
Authors
Ola Samir El-Shimi Amina Ali Farag Amany Mohammed El-Rebigi
Taghrid Gamaleldin Kharboush Hanaa El-Sayed Bayomy Rana Atef Khashaba
Keywords
Carbamazepine; immunological effects ; hematological effects; children; Egypt
Journal
Journal of Child Science
Publisher
Not Available
Volume
11
Issue
1
Pages
e265-e272
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Carbamazepine (CBZ) is one of the oldest antiepileptic drugs (AEDs) that is still used for
the treatment of tonic-clonic seizures in children. Long-term use of AEDs induces
potential toxic effects that may remain undetermined for a long time. Earlier studies
have revealed a wide spectrum of hematological toxicities associated with CBZ. This
study was conducted to unveil the toxic effects of carbamazepine as an antiepileptic
monotherapy on hematological and immunological parameters in a group of Egyptian
pediatric patients using it for different durations. Fifty pediatric epileptics of either sex
were enrolled; 38 were taking CBZ as antiepilepticmonotherapy for6months and 12
were newly diagnosed untreated patients. Hematological and immunological parameters
studied were compared with their age and sex-matched 15 controls and among
groups. CBZ was found more toxic for total leukocyte count, lymphocyte count, serum
IgA and IgM levels (p
the treatment of tonic-clonic seizures in children. Long-term use of AEDs induces
potential toxic effects that may remain undetermined for a long time. Earlier studies
have revealed a wide spectrum of hematological toxicities associated with CBZ. This
study was conducted to unveil the toxic effects of carbamazepine as an antiepileptic
monotherapy on hematological and immunological parameters in a group of Egyptian
pediatric patients using it for different durations. Fifty pediatric epileptics of either sex
were enrolled; 38 were taking CBZ as antiepilepticmonotherapy for6months and 12
were newly diagnosed untreated patients. Hematological and immunological parameters
studied were compared with their age and sex-matched 15 controls and among
groups. CBZ was found more toxic for total leukocyte count, lymphocyte count, serum
IgA and IgM levels (p