Central venous access devices (CVADs) are used within a variety of areas in both hospital and community health care settings to administer blood or fluids, to provide long term access for repeat transfusion of blood or blood products, chemotherapy, parenteral nutrition and antibiotic therapy, and to provide immediate access in emergency situations. Nurses who are knowledgeable and competent in the basic aspects of CVADs care able to ensure specific patients' needs are met and prevent further complications. The aim of this study: To study the impact of Intensive Care Unit Nurse's knowledge on Care of Patients with central venous access devices. Subjects and Methods: A descriptive design was utilized at Intensive care unit in Benha University Hospitals and Zagazic University Hospitals. The study included 100 nurses who cared for patients undergoing CVADs insertion were enrolled in this study. Tools of the study involved sheet to collect data related to nurses' demographic data and implantable port catheter care knowledge questionnaire were utilized. Results: the impact of Intensive Care Unit Nurse's knowledge on Care Processes of Patients with central venous access devices the study revealed that two third of nurses received in-service training programs about the CVADs. Also, it revealed two thirds of the studied subjects have got satisfactory knowledge level. The present study showed high significant differences among the nurses' level of knowledge by their age and educational qualifications and total knowledge scores. Conclusion: The majority of the nurses had got satisfactory level and there was significant correlation between the nurses' knowledge level and their demographic characteristics. Recommendations: An educational programs and in-service training courses should be provided to nursing staff working in Intensive Care Unit regarding CVADs implantation care according to the updated standards and guidelines.