Asthma is a chronic inflammatory lung disease characterized by airway obstruction, airway hyperresponsiveness, and airway inflammation, all of which are variable among patients and variable in time within any specific patient. The study aimed to evaluate the effect of an educational program regarding self-care strategies for patients with bronchial asthma on their knowledge and practice. Research design: A quasi-experimental research design was utilized in this study. Setting: The current study was performed in the chest department at Benha University Hospital. Subjects: The study included (100) adult patients with bronchial asthma with previous attacks. Tools of data collection: Three tools were used for data collection: Tool I- Patients’ assessment questionnaire which included two parts. a) Patients’ sociodemographic characteristics & health history, b) Structured knowledge questionnaire to assess patients’ knowledge regarding the disease, Tool II-Observational checklist to assess patients’ practice, and Tool III-patients’ self-care strategies used to control physiological problems. Results: Revealed that the majority of patients had poor knowledge, practice, and self-care strategies before implementation of the program, which improved post program implementation. Conclusion: The results had shown many areas of deficit in patients’ knowledge, practice, and self-care strategies prior application of the program which reflects a need for further continuous education which will provide patients with some directions that will help to manage complications. Recommendations: The study recommended for further continuous educational programs to be conducted on larger number of patients to improve their knowledge, practice, and self-care strategies.