Clinical examination of 100 diarrheic buffalo calves from different farms at Qualiobya province was performed. Diarrhea, apathy, lack of appetite, mild fever and dehydration were the major signs observed. For the goal of treating Cryptosporidiosis, Two treatment trials were conducted in this study on 36 naturally Cryptosporidium-infected buffalo calves using garlic and Nitazoxanide (NTZ). There was a gradual reduction in oocyst counts in garlic and NTZ treated animals; this reduction was more obvious in garlic than NTZ treated groups and continued till reaching negligible degree or no oocysts detection at 15 to18 days post treatment in garlic and at 3 weeks in NTZ treated animal groups. Then, after one week, the majority of NTZ treated calves excreted oocysts at low level. Oocysts observed during treatments were found to be deformed in shape. Dealing with biochemical changes, there was a significant increase in RBCs and WBCs counts, Hemoglobin concentrations, PCV and potassium levels and a significant decrease in total protein, albumin and globulin concentrations, A/G ratio, glucose, sodium, chloride, iron and copper concentrations in the infected animals than the healthy ones. Almost all biochemical parameters tested enhanced in their concentrations towards the healthy normal status after treatments. Garlic offered a promising effect in the treatment of cryptosporidiosis.