Laboratory experiments were carried out to spot light on the effect of some plant extract treatments on levels of total protein, carbohydrates, lipids and glucose, as well as on the activity of peroxide, catalase and alkaline phosphatase (ALP) enzymes in E. vermiculata snail. Results revealed that the least level of total protein was recorded among animals treated with 10% Nerium oleander plant extract (6.30mg/ml), while level of carbohydrate was the least by Eucalyptus melliodora plant extract treatment at 10% concentration (1.41 mg/ ml). On the other hand, the highest reduction of total lipids and glucose levels were recorded after treatment by Azadirachta indica plant extract at 10% concentration. The present data showed also the highest activity of peroxidase and catalase enzymes after Eucalyptus melliodora plant extract 20% treatment and the least activity for the same two enzymes occurred by Nerium oleander treatment. In addition, the highest reduction of (ALP) activity was registered after treatments by extracts of Nerium oleander and Azadirachta indica extracts.