Staff Members - Benha University
Prognostic value of CD44 and Her2/neu in invasive transitional cell carcinoma of the urinary bladder
Medical Journal of Cairo University • 2014
Publication Information
Authors
Ghada A. Abd El-Fattah (MD), Rasha M. El-Sawi (MD), and Rasha M. Abd-Rabuh (MD), Pathology Department, Faculty of Medicine, Benha University
Keywords
CD44, Her2/neu, Transitional cell carcinoma (TCC), immunohistochemistry (IHC).
Journal
Medical Journal of Cairo University
Publisher
Not Available
Volume
82
Issue
2
Pages
Not Available
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Purpose: Urinary bladder cancer is a very common worldwide cancer. In Egypt, there was a significant rise in the incidence of TCC in the last years. CD44 is a transmembrane glycoprotein thought to play an important role in cell-cell and cell-matrix interactions. HER-2/neu is an oncogene. Its overexpression has been associated with some different types of human cancers. The present study aimed at evaluating the prognostic value of CD44 and Her2/neu in invasive TCC of urinary bladder.
Patients and Methods: This study includes 6 cases of normal bladder mucosa as a control and 40 cases of TCC (15 cases of grade 2 and 25 cases of grade 3). Cases were collected from Pathology Department, Faculty of Medicine- Benha University and Egyptian National Cancer Institute (NCI) in the period 2009-2011. Follow up of the selected cases was recorded for 2 years. Immunohistochemical staining for CD44 and Her2/neu was performed in all cases and the patterns of expression were analyzed.
Results: The expression of CD44 was higher in control cases than TCC and was significantly decreased in cases with poor patient prognosis (p
Patients and Methods: This study includes 6 cases of normal bladder mucosa as a control and 40 cases of TCC (15 cases of grade 2 and 25 cases of grade 3). Cases were collected from Pathology Department, Faculty of Medicine- Benha University and Egyptian National Cancer Institute (NCI) in the period 2009-2011. Follow up of the selected cases was recorded for 2 years. Immunohistochemical staining for CD44 and Her2/neu was performed in all cases and the patterns of expression were analyzed.
Results: The expression of CD44 was higher in control cases than TCC and was significantly decreased in cases with poor patient prognosis (p