| publication name | Value of CD34 and CD10 immunostaining in the differentiation between basal cell carcinoma and trichoepithelioma |
|---|---|
| Authors | Mohebat H. Gouda (MD), Ghada A. Abd El-Fattah (MD), and Adel Z. El-Saediy (Ass.Prof.) Pathology Department, Faculty of Medicine, Benha University |
| year | 2014 |
| keywords | CD34, CD10, basal cell carcinoma (BCC), trichoepithelioma (TE), immunohistochemistry (IHC). |
| journal | Medical Journal of Cairo University |
| volume | 82 |
| issue | 2 |
| pages | Not Available |
| publisher | Not Available |
| Local/International | Local |
| Paper Link | Not Available |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
Purpose: Trichoepithelioma (TE) is a benign skin tumor with follicular differentiation, which is sometimes difficult to distinguish clinically and histologically from basal cell carcinoma (BCC). Both are characterized morphologically by the proliferation of basaloid cells; however, BCCs are clinically associated with a more aggressive behavior. It is important to distinguish these neoplasms for effective and appropriate therapeutic planning. The present study aims at investigating the role of CD10 & CD34 in differentiation between TE and BCC. Patients and Methods: This study includes 30 cases of BCC and 10 cases of TE. Cases were collected from Pathology Department of Faculty of Medicine- Benha University and Egyptian National Cancer Institute (NCI) in the period 2008-2013. CD34 and CD10 immunohistochemistry was performed in all cases and the patterns of expression were analyzed. Results: The pattern of CD34 expression in BCC copmared to that of TE was statistically significant (p