Staff Members - Benha University
Role of T helper 17 Cells in the Pathogenesis of Systemic Lupus Erythematosus
EGYPTIAN JOURNAL OF IMMUNOLOGY • 2012
Publication Information
Authors
Ahmed T Abou Ghanima, Gehan G Elolemy, Sahar S Ganeb, Abeer A Abo Elazem, Eman R Abdelgawad
Keywords
T helper 17 Cells ,Systemic Lupus Erythematosus
Journal
EGYPTIAN JOURNAL OF IMMUNOLOGY
Publisher
Not Available
Volume
19
Issue
2
Pages
25-33
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disorder that occurs in genetically prone
individuals. Autoimmunity could not be simply explained by Th1/Th2 cell paradigm. T helper 17(Th17) cells
producing the cytokine interleukin-17 (IL-17) may explain the promotion and progression of autoimmune
phenomena. This study aimed to investigate the role of Th17cells, IL-17 and interleukin-23 (IL-23) in the
pathogenesis of SLE and their correlation with disease activity. The frequencies of circulating Th17 cells in
15 patients with active SLE, 15 patients with inactive disease and 15 healthy control subjects were measured
using Flowcytometry after stimulation with phorbol myristate acetate (PMA) and ionomycin for 4 hours.
Serum levels of IL-17 and IL-23 were measured using the enzyme linked immunosorbent assay (ELISA).
Significantly higher mean frequencies of circulating Th17 cells were found in active SLE patients (1.54 ±
0.38%, P
individuals. Autoimmunity could not be simply explained by Th1/Th2 cell paradigm. T helper 17(Th17) cells
producing the cytokine interleukin-17 (IL-17) may explain the promotion and progression of autoimmune
phenomena. This study aimed to investigate the role of Th17cells, IL-17 and interleukin-23 (IL-23) in the
pathogenesis of SLE and their correlation with disease activity. The frequencies of circulating Th17 cells in
15 patients with active SLE, 15 patients with inactive disease and 15 healthy control subjects were measured
using Flowcytometry after stimulation with phorbol myristate acetate (PMA) and ionomycin for 4 hours.
Serum levels of IL-17 and IL-23 were measured using the enzyme linked immunosorbent assay (ELISA).
Significantly higher mean frequencies of circulating Th17 cells were found in active SLE patients (1.54 ±
0.38%, P