Background: perimenopause represents a critical life stage encompassing a range of physiological and psychosocial changes that require adaptions to optimize health and functioning. Aim of this study was apply an educational program on lifestyle of peri- menopausal women utilizing PRECEDE-PROCEED model. Design: Quasi-experimental equivalent study. Setting: Administrative Building of Benha University hospitals. Sample: a purposive sample was selected according to inclusion and exclusion criteria. The sample consisted of two groups (Study group comprising 55 perimenopausal women who received the educational program and control group comprising 54 peri-menopausal women who didn’t not receive).Tools: the tools of data collection were a structured interviewing questionnaire sheet, and health promoting lifestyle profile. Results: there was a highly statistically significant difference was observed in predisposing factors, reinforcing factors, enabling factors and health promoting lifestyle of the study group compared with the control group after three and six months of PRECEDE - PROCEED model application (p < 0.001). Conclusion: The PRECEDE - PROCEED model provided an excellent framework for health intervention programs especially in enhancing lifestyle, and improved the understanding of the relationship between variables such as predisposing factors, reinforcing factors, enabling factors and lifestyle. Recommendations: PRECEDE - PROCEED model must be applied in the process of education by considering all effective personal, environmental, and social factors to change the lifestyle of women.