Staff Members - Benha University
Body mass index, hepatic fibrosis and infalmmation in chronic hepatitis C:a retrospective study
Zagazig University Medical Journal • 2004
Publication Information
Authors
Dr/ Sabry Anis, Dr/ Reda El Badwy, Dr/ Galal Mowaed, Dr/ Entsar El sharkawy, Dr/ Magdy Gad, Dr/ Hossam Amin, Dr/ Aza Abo Sena
Keywords
Not Available
Journal
Zagazig University Medical Journal
Publisher
Not Available
Volume
10
Issue
2
Pages
684-692
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
OBJECTIVE:
Little is known about the relationship between elevated serum α-fetoprotein (AFP) levels and insulin resistance, which adversely influence the clinical course of chronic hepatitis C (CHC). Therefore, we investigated the association between serum AFP and insulin resistance in patients with CHC.
METHODS:
We retrospectively investigated 300 patients with CHC without hepatoma who underwent liver biopsies and oral glucose tolerance tests. Patients taking antidiabetic drugs were excluded. We analyzed factors associated with elevated AFP levels (≥ 10.0 ng/mL) in 265 eligible patients. Twenty patients with a homeostasis model assessment for insulin resistance value of ≥ 2.0 and a whole-body insulin sensitivity index of
Little is known about the relationship between elevated serum α-fetoprotein (AFP) levels and insulin resistance, which adversely influence the clinical course of chronic hepatitis C (CHC). Therefore, we investigated the association between serum AFP and insulin resistance in patients with CHC.
METHODS:
We retrospectively investigated 300 patients with CHC without hepatoma who underwent liver biopsies and oral glucose tolerance tests. Patients taking antidiabetic drugs were excluded. We analyzed factors associated with elevated AFP levels (≥ 10.0 ng/mL) in 265 eligible patients. Twenty patients with a homeostasis model assessment for insulin resistance value of ≥ 2.0 and a whole-body insulin sensitivity index of