Background: Female patients with anogenital warts often suffer from anxiety of the effect of the disease on their sexual and social relationships that negatively affect the quality of life of woman. Objective: To evaluate the female sexual dysfunction (FSD) and QOL among married women suffering from genital warts (GWs). Patients and Methods: Fifty married women suffering from GWs with established marital relationships were enrolled in this study. A questionnaire formula distinguished by authors was applied for the contributors. Results: About 98% of the participants had sexual problems with total FSFI score17.2±6.2. FSD correlated with declined quality of life. Conclusion: Genital warts have negative wide-ranging effects on patients’ quality of life and sexual functions.