Background: knowledge and attitude about safe motherhood practices could help not only to reduce pregnancy related health risks but also helps in improving maternal and child health. Aim: of this research was to evaluate the effectiveness of comprehensive intervention package on pregnant women's perception regarding selected aspects of safe motherhood. Design: A quasi- experimental design was utilized. Sample: A purposive sample of (154 pregnant women) (One Group Pre-test Post-test design). Setting: The research was carried out in obstetrics & gynecology outpatient clinic at Benha university hospital. Tools: Data were collected through three main tools: A self-administered questionnaire to assess women's socio-demographic characteristics and obstetrical history, maternal knowledge questionnaire, modified likert scale to assess women's attitude. Results: showed that the mean age of studied sample 22.9±6.87 years. There was improvement with a highly statistically significant difference observed in women's knowledge and attitude regarding all aspect of safe motherhood at post-intervention phase compared with pre- intervention phase (p