Background: The possibility that the association of inflammation with AF and the related thromboembolic risk could be examined with the use of C-reactive protein(CRP) has captured the attention of many researchers (Versaci et al., 2002; Boss and Lip 2005; Watanabe et al., 2005; Guazzi and Arena,2009). Methods: This study on 100 patients from those referred to transesophageal echocardiography for cardioversion or assessment of left atrial appendage in AFib with stroke. All patients were subjected to history taking (Age, DM, HTN, previous stroke, IHD, PVD). physical examination Resting 12- lead surface ECG. Transthoracic echocardiography to detect LA diameter, LA area and EF. Transesophageal echocardiography to detect LAA SEC, thrombus, emptying and filling velocities. Measurement of hs-crp. Results: demographic and clinical characteristic including DM, and HTN, IHD,SEX has no significant effect on hs-CRP, but CRP concentration was associated positively with age with significant difference between examined groups (p = 0.003) and PVD with significant difference between examined groups ( p = 0.001). hs- CRP concentration was significantly elevated in patients with prior stroke (p