This study was carried out to determine the effects of Prebiotic, Probiotic and Synbiotic in diets on broiler growth performance, carcass measurements, blood picture, serum glucose, calcium and phosphorus levels, liver function, and economical evaluation. Five hundred Sasso chicks (1-day-old) were used. The dietary treatments were as follow: basal diet (control); Basal diet plus 0.5 kg of probiotic Lactic dry®/ton of the feed; basal diet plus 1 kg of prebiotic Bio-MOS®/ton feed; and basal diet plus 0.5 kg of Lactic dry® and 1 kg Bio-MOS®/ton feed, respectively. Dietary supplementation of probiotic, prebiotic and synbiotic (probiotic with prebiotic) improved body weight gain, feed conversion ratio and breast muscle percentage. However, they did not affect liver enzymes. The prebiotic and synbiotic supplementation caused statistically significant increase in the erythrocyte count, hemoglobin concentration and haematocrit values comparatively with control values. Glucose, cholesterol, LDL, and Triglycerides concentrations showed significant decrease. Significant increase was recorded in calcium levels in prebiotic and symbiotic groups. Economical efficiency of the feed additives was improved. The results of the present study showed that synbiotic provide additive benefits in growth performance, feed conversion ratio, hematological and biochemical parameters than that of individual use of these additives.