Kaluobia governorate, five of them were clinically normal and free from internal and external parasites, while the remaining 13 lambs suffered from bloody diarrhea and their feces had vegetative cells and oocytes of Eimeria. species. Hematological picture indicated significant decrease of erythrocytic count and hemoglobin concentration, while there was significant increase of PCV % and total leukocytic count. Differential leukocytic count showed neutrophilia, lymphopenia and eosinophilia. Serum analysis revealed significant decrease of sodium, iron, zinc, chloride, bicarbonate and total protein levels with significant increase of potassium, total bilirubin, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase and alkaline phosphatase activities. Also there were no changes of serum calcium, glucose and copper levels. Treatment of coccidiosis of lambs with sulfadimethoxine was more effective and faster than amprolium treated lambs.