Continuous positive airway pressure (CPAP) is used when the preterm neonate is breathing spontaneously without a mechanical ventilator. Nursing care provided to preterm neonates undergoing CPAP is essential for improvement neonates' condition. The study aimed to improve nursing care provided to preterm neonates undergoing CPAP ventilation. This study was carried out at Neonatal Intensive Care Units of Specialized Pediatric Hospital at Benha city. Sample of the study was a convenient sample for nurses and purposive sample for preterm neonates who consisted of 55 preterm neonates on CPAP and 55 nurses who cared for them at previously mentioned settings. Tools of data collection included three tools, (1) A structured Interviewing Questionnaire Sheet which composed of personal data of the nurses and Nurses, knowledge regarding nursing care for preterm neonates undergoing CPAP ventilation, (2) Medical Record of Preterm Neonates undergoing CPAP Ventilation, and (3) observational checklist for nursing care provided for preterm neonates undergoing CPAP ventilation. The main results of this study revealed that, there was highly statistical significant improvement in the studied nursesʹ total level of knowledge and total performance post program implementation. The main recommendation is conducting an orientation programs for nurses in NICU with regular updates of knowledge and practice regarding continuous positive airway pressure