Sixty three patients with documented chronic liver disease, either due to hepatic schistosomiasis or due to chronic viral hepatitis, single or in combination, were evaluated as regard biochemical renal profile determination for all patients as well as percutaneous renal biopsy for most cases (56) with light microscopic and immunofluorescent examination. We found that nephrotic syndrome is the main presentation in older patients, especially in HCV hepatitis patients, while proteinuria is mainly presented in schistosomiasis patients. All histopathological forms of glomerular involvement (mesangial proliferation, membranoproliferative, membranous, focal segmental and renal amyloidosis ) were encountered in schistosomiasis patients as well as viral hepatitis patients, with membranoproliferative predominance in HCV patients (39%). Mixed cryoglobulinemia was documented in 6(9.5%) HCV cases. Renal amyloidosis was present in 3.18% of nephrotic cases. The most common immunoglobulin was IgM, While C3 was the most common complement among the study population . KEY WORDS : Hepatic schistosomiasis - viral hepatitis - nephropathy