Myocardial infarction (MI) is an irreversible injury or subsequent necrosis of myocardial cells due to interruption of blood supply to a part of the heart.The present study was designed to evaluate the effect of ezetimibe , atorvastatin and their combination on model of induced acute myocardial infraction with hypercholesterolemic rats . Animals were classified into group 1:control group which was subclassified to normal control group ( received standered chow) and vehicle group (received 0.5% carboxy methyl cellulose) ,group 2: hypercholestermic group with no medication (induced by 2% cholesterol for 6 weeks ) group 3:hypercholestermic infracted group with no medication (diseased group) (induced by s.c injection of single dose of isoprenaline ( 150mg/kg diluted in 2ml of saline) , group 4: Atorvastatin (8mg/kg) pretreated hypercholesterolemic infarcted group ,group 5: Ezetimibe (1mg/kg) pretreated hypercholesterolemic infarcted group,Group 6: Ezetimibe (1mg/kg) and atorvastatin (4mg/kg) pretreated hypercholesterolemic infarcted group,Group7: Ezetimibe (1mg/kg) and Atorvastatin (8mg/kg) pretreated hypercholesterolemic infarcted group..All tested drugs showed improvement of lipid profile, compared to control normal group and diseased group. All treated groups showed significant results compared to ezetimibe 1mg/kg alone.RegardingMI, Atorvastatin ( 8mg/kg) only showed improvement of parameters of MI ,but ezetimibe had no role.