infectious multidrug resistance bacteria is become a major health problem and limited the option for effective treatment in human population worldwide. New antimicrobial agents are urgently required to overcome this issue. The present study aimed to evaluate antibacterial activities of honey and some herbal plant extracts (Ginger, Clove and Black cumin) against Staphylococcus aureus, Staphylococcus epidemdis, Escherichia coli & Klebsiella pneumonia by using disc diffusion method and broth microdilution assays. Herbal plants and honey samples were purchased from local market at Al-Quwyiyahia, Saudi Arabia. Also, Egyptian honey purchased from local market at Egypt. Herbal plants extracted with water /ethanol solvent and evaluated for antimicrobial activity against bacteria isolated from clinical and water samples. The results indicated that the highest bacterial resistance to antibiotics Escherichia coli (57.14 %) followed by Klebsiella pneumonia (42.28 %) and Staphylococcus aureus (28.57 %). The Egyptian and Saudi laguanza honey were showed strong antibacterial effects and inhibitory effect with concentrations of 50, 20% and 10% followed by Clove and Black cumin ethanolic extracts against tested bacteria. Combination honey with antibiotics or plant extracts mixture (v/v) revealed synergistic effects on tested bacteria. Finally our study proved that the Egyptian and Saudi laguanza honey have strong antibacterial effect depended upon the quality, type and concentration. The marked effect of new formula from combination plant extracts and honey have broad spectrum antimicrobial activity at low concentration 0.0325 mg/ml. but still need further extensive studies should done to spotlight the hidden properties of these plant extracts and honey.