Staff Members - Benha University
Significance of tumoral and stromal ALDH1A1 expression in breast invasive duct carcinoma in Egyptian female patients
Egyptian Journal of Pathology • 2019
Publication Information
Authors
Ghada A. Abd El-Fattah (MD), Enas Ibrahim (MD), Sarah N. Nasif(MD).
Keywords
breast cancer, invasive duct carcinoma, ALDH1A1.
Journal
Egyptian Journal of Pathology
Publisher
Not Available
Volume
39
Issue
1
Pages
151-158
publication.type
Local
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Abstract:
Background: cancer is considered a stem cell disease. Many stem cell markers are recently well-known to have main roles in carcinogenesis and tumor progression. ALDH1A1 is a stem cell marker that thought to have a role in many cancers. This study aimed to evaluate the expression of ALDH1A1 in different molecular types of breast invasive duct carcinomas, and its relation to clinicopathological data
Material and Methods: This is a retrospective study carried upon 40 cases of invasive ductal carcinoma (NOS) of the breast. Cases were collected form archives of Early Cancer Detection Unit (ECDU), Benha Faculty of Medicine and pathology department, International Medical Center, between the years 2007-2013. Previously ER, PR, Her2/neu and Ki67 stained slides were re-evaluated for each case. Both tumoral and stromal expression of ALDH1A1 was also evaluated for each case.
Results: A significant positive correlation of ALDH1A1tumoral expression was observed in patients with age >55 years (p
Background: cancer is considered a stem cell disease. Many stem cell markers are recently well-known to have main roles in carcinogenesis and tumor progression. ALDH1A1 is a stem cell marker that thought to have a role in many cancers. This study aimed to evaluate the expression of ALDH1A1 in different molecular types of breast invasive duct carcinomas, and its relation to clinicopathological data
Material and Methods: This is a retrospective study carried upon 40 cases of invasive ductal carcinoma (NOS) of the breast. Cases were collected form archives of Early Cancer Detection Unit (ECDU), Benha Faculty of Medicine and pathology department, International Medical Center, between the years 2007-2013. Previously ER, PR, Her2/neu and Ki67 stained slides were re-evaluated for each case. Both tumoral and stromal expression of ALDH1A1 was also evaluated for each case.
Results: A significant positive correlation of ALDH1A1tumoral expression was observed in patients with age >55 years (p