Background: Kidney transplantation is a life-saving alternative to dialysis for patients with advanced, irreversible renal failure, which extending the survival, improving the quality of life, and decreasing in the mortality associated with long-term dialysis. Aim: The aim of this study was to evaluate the effectiveness of educational programs for health-promoting lifestyle among patients (recipients) with kidney transplantation. Research design: A quasi-experimental design was utilized in the present study. Setting: This study was conducted at Out-Patients Clinic for follow-up kidney transplantation in Nasr City Health Insurance Hospital. Sample: Purposive sample of 106 patients (Intervention group 54 & control group 52). Tools: Three tools were utilized for data collection, (I) A structured interview questionnaire for patients, (II) A health-promoting lifestyle profile, and (III) The Kidney Transplant Patient‘s Quality of Life. Results: There was highly statistically significant difference in knowledge scores between the intervention and control group, as well as a significantly higher scores of health promoting lifestyle behavior, and quality of life of intervention compared to control group. It also showed a significant association between knowledge and health promoting lifestyle behavior as well as quality of life of patients with kidney transplantation after educational program implementation. Conclusion: The intervention group benefited from the educational program that increased their knowledge, encouraged healthy lifestyle behaviors, and improved their quality of life. Recommendations: Written, a simple booklet about health-promoting lifestyle behavior post-transplantation should be available for patients and their families (relatives) at the Out-Patients Clinic for follow-up kidney transplantation in Nasr City Health Insurance Hospital.