Aim: The aim of the study was to evaluate the effect of emergency contraception guidelines on women's knowledge and attitude. Design : A quasi-experimental study was utilized Setting: the study conducted in Obstetrics and Gynecological Out Patient Clinic at Benha University Hospital . Sampling: A convenient sample including all women admitted to Out Patient Clinic for a period of six months were collected after approving to participate in the study and utilizing emergency contraception guidelines intervention. Tools: Two tools were used :1- A structure interviewing questionnaire included a) Socio demographic data of studied women. b) women’s knowledge about emergency contraception. II- Likert scale tool to assess women’s attitude toward emergency contraception . Results: There is a poor knowledge about emergency contraceptives among studied women , 55.0% do not know emergency contraceptives. also more than one third 38.5% had unwanted pregnancies prior to the time of the study. In addition , 55.0% had negative attitude pre intervention toward emergency contraceptives, There was highly significant improvement in women’ knowledge score and significant positive attitude post intervention. Conclusion: There was a highly significant improvement in women’ knowledge, and attitude after application of guidelines intervention about emergency contraception. This supported the main hypotheses of the study. Recommendations: The study recommended provision of the guidelines about emergency contraception in different hospitals and maternal child centers to improve women's knowledge and attitude