Purpose: to use the regimen of ketogenic diet (modified atkin diet) in addition to anti-epileptic drugs in controlling cases of intractable epilepsy and compare the results with cases receiving anti-epileptic drugs only from one month to 36 months. Subjects and methods: This is a case control study which was performed on 15 cases of refractory epilepsy received anti-epileptic drugs and follow ketogenic diet (modified atkin diet) which are the cases , and 15 patients with refractory epilepsy received antiepileptic drugs only which are the control with age ranging from 1-36 months and mean age(1.63 ± 1.13). Results: showed that, the frequency of convulsions before diet ranged from 2 to 40 with mean 12.4 and standard deviation( SD) 10.769 compared to the frequency of convulsions after diet ranged from 0 to 10 with mean 2.20 and standard deviation 2.95 and there was statistically significant difference between the two groups (P. value was 0.001). There was no statistically significant difference between lipid profile of the patients before diet and after diet. Mean ± standard deviation of Quality Of Life (QOL) scores was 15.71 ± 1.38 before diet which changed to 25.57 ± 3.41 after diet .This difference was statistically significant (P. value was 0.000). Conclusion: Modified atkin diet (MAD) improved patients with intractable epilepsy as regards to frequency of convulsions and quality of life.