The objective of this study was to investigate
the dietary effect of vitamin C in amelioration
some of studied alterations induced by fenitrothion in
Nile tilapia (Oreochromis niloticus). Nile tilapia was
exposed to sub-lethal concentration of fenitrothion
0.04 mg/l (96 h LC50 value was 0.8 mg/l), and basal
diet was supplemented with two different dose of
vitamin C (500 and 1200 mg/kg B wt/day) for
30 days. Vitamin C supplemented groups showed
significant decrease in plasma cortisol and glucose
level, enzymes activity of liver and gills (catalase,
glutathione-S-transferase and superoxide dismutase)
and % of tail DNA damage compared to exposed
group. Moreover, fish revealed significant increase in
total plasma protein, albumin, globulin and A/G ratio.
High dose of vitamin C dietary supplementation
(1200 mg/kg B wt/day) returns these parameters to
its normal levels with no significant difference compared
to non exposed control group. These results
indicated that incorporation of high dose of vitamin C
(1200 mg) in aqua feed for 30 days could be
potentially less expensive and effective in reducing
the alterations induced by fenitrothion in Nile tilapia