Abstract: It is often painful to both the surgeon and the patient when wound complication develops or when the wound outcome post coronary artery bypass grafting (CABG) is suboptimal. Our aim in this study was to analyze anatomical variations and perioperative risk factors leading to leg wound infection post CABG at the graft harvesting site. A retrospective study was carried out on 1251 patients who underwent CABG surgery. They were classified into 2 groups: The demographic, operative and postoperative data were collected and statistical analysis was performed to assess risk factors predisposed to leg wound infection post CABG in both groups. The study included 2 groups, group I: who had infected leg wound: (n= 76, 6.1%) and group II: non infected cases post CABG: (n=1175, 93.9%). Multivariate analysis for risk factors showed that high lipid profile was significantly associated with leg wound infection (p-value= 0.005), Odds ratio 3.769 (95% CI 1.5-9.45). Peripheral arterial disease also was significant finding (P-value=0.021), Odds ratio 1.98(95% CI 1.34 -3.45) as well as hypoalbuminemia (p-value=0.043), Odds ratio 1.32 (95%CI 1.02-2.32). The highest correlation was documented in the presence of unusual course of saphenous vein (p-value= 0.004), Odds ratio 5.44 (95% CI 3.21-6.85). On the other hand the demographic data as age, sex and BMI were not significant risk factors for leg wound infection in multivariate analysis model. The knowledge and identification of anatomical variations of GSV play an important role in increasing the success and improving outcome post-surgical intervention.