Context: The night shift work can have a negative impact on job performance, sleep, physical and emotional health, social life, family life, and level of job –related stress for nurses. Aim: This study aimed to evaluate the effect of coping strategies program on quality of life among emergency clinic nurses working at night shift. Methods: A quasi-experimental design was utilized to fulfill the aim of this study. The study was conducted at Emergency Clinic affiliated to Benha University Hospital. A convenience sample was used to achieve the aim of this study. It includes all nurses (60 nurses) who worked at night shift at Emergency Clinic. Three tools utilized in this study: Three tools were utilized in this study: Structured interviewing questionnaire to assess nurses' data, ways of coping scale for measuring coping abilities of nurses working at night shift. It included 45 items comprising eight subscales. The quality of life scale, which was designed for measuring the quality of life for nurses, consisted of 34 items categorized based on the quality of life in three domains. Results: A result reveals that there is a significant difference between nurses' quality of life and their coping abilities post-program implementation (P= 0.001) compared to the pre-intervention level. A positive significant correlation coefficient between nurses coping strategies and their quality-of-life post-program implementation (r= 0.40, p=