Background: Urolithiasis is a common and important problem in urinary tract and the prevalence of the disease is especially rising in recent years due to changing the lifestyle and diet. Aim: This aimed to evaluate effect of self-care intervention for patients with urolithiasis on their practices regarding nutrition. Research design: Quasi experimental design was utilized to fulfill the aim of this study. Setting: This study conducted in urology department and the urology outpatient clinic at Benha University Hospital. Sample: Purposive sample of 84 male and female patients suffering from urolithiasis. The study subjects was divided into two equal groups, the study group (42) and the control group (42). Tools: Two tool used in this study. I: Structured interviewing questionnaire; it includes three parts: personal characteristics of patients, patients' medical history and patients’ self-care knowledge. Tool II: self-care practices: it includes consumption of permitted foods, consumption of restricted foods, consumption of fluids and practices regarding urolithiasis. Results: The majority of both study and control group patients were respectively married, male, worker and more than half of them their age range from 40-60 years old. There was statistically significant difference between the two groups regarding their knowledge and self care practices post intervention compared to pre intervention(p < 0.05), with an improvement in self-care practices among the study group compared to the control group post self-care intervention. Conclusion: Self-care intervention for study group had a favorable effect on improving their knowledge and self care practices regarding nutrition. Recommendations: Continuous educational programs should be planned and offered on regular basis for patients with urolithiasis