Background
Colorectal cancer (CRC) is one of the most frequent cancers worldwide. Cyclin D1
(CNND1) and cyclooxygenase-2 (Cox-2) are expressed in a plethora of neoplastic
tissues.
Aim
The present work was conducted to examine the immunohistochemical expression
of CNND1 and Cox-2 in colorectal adenocarcinoma, compared with colonic
adenoma to evaluate its association with various clinicopathological features.
Patients and methods
A total of 30 colorectal adenocarcinoma cases, 20 cases of colonic adenoma, and
10 normal colonic mucosal biopsies as controls were studied. Immunohistochemical
technique was applied to detect CNND1 and Cox-2 expression and correlate them
with clinicopathological findings.
Results
Both cytoplasmic high CNND1 and nuclear positive Cox-2 expression were
significantly increased from normal colonic mucosa (0 and 10%, respectively)
to CRC (80 and 83.3%, respectively) passing through colon adenoma (25 and
55%, respectively) (P≤0.001 for both). High CNND1 score was significantly related
to lymph node spread and stage (P≤0.001 for both). A statistically significant
difference was documented between Cox-2 and grade of differentiation (P=0.017),
distant metastasis, and TNM stage (P=0.033, 0.003, respectively).
Conclusion
The present work suggests the oncogenic role of CNND1 and Cox-2 in CRC.
Furthermore, overexpressions of CNND1 and Cox-2 are associated with poor
prognostic factors, implicating their potentially prognostic role in CRC.