Staff Members - Benha University
Interleukin -37 as an anti-1 inflammatory cytokine: Does its relation to disease activity suggest its 2 potential role in rheumatoid arthritis therapy?
Egyptian Rheumatology and Rehabilitation • 2021
Publication Information
Authors
Eman Baraka1, Mona Balata2,3, Shereen Ahmed4,Afaf Khamis5 and Enas Elattar2
Keywords
Not Available
Journal
Egyptian Rheumatology and Rehabilitation
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
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publication.type
Local
Paper Link
Not Available
Supplementary Materials
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Abstract
Background: This study aimed to measure the serum and synovial interleukin (IL) -37 levels in
5 rheumatoid arthritis (RA) patients compared to patients with primary knee osteoarthritis (PKOA) and
6 healthy controls and to detect its relation to RA disease activity. Results: This cross-sectional study
7 included 50 RA patients with a mean age of 40.24±8.62 years, 50 patients with PKOA with a mean age
8 of 56.69±4.21, and 40 healthy controls with a mean age of 41.75 ±7.38 years. The mean serum IL-37
9 level in the RA patients (382.6±73.97 pg/ml) was statistically significantly (p 0.94). Both serum and
12 synovial IL-37 levels were significantly positively correlated with disease activity scores (r= 0.92, P<
13 0.001 and r= 0.85, P< 0.001), tender joint counts (r= 0.83, P< 0.001 and r= 0.82, P< 0.001 ), swollen
14 joint counts (r= 0.72, P< 0.001 and r= 0.60, P< 0.001), visual analogue scores (r=0.82, P< 0.001 and r=
15 0.82, P< 0.001), erythrocyte sedimentation rate (r= 0.75, P
5 rheumatoid arthritis (RA) patients compared to patients with primary knee osteoarthritis (PKOA) and
6 healthy controls and to detect its relation to RA disease activity. Results: This cross-sectional study
7 included 50 RA patients with a mean age of 40.24±8.62 years, 50 patients with PKOA with a mean age
8 of 56.69±4.21, and 40 healthy controls with a mean age of 41.75 ±7.38 years. The mean serum IL-37
9 level in the RA patients (382.6±73.97 pg/ml) was statistically significantly (p 0.94). Both serum and
12 synovial IL-37 levels were significantly positively correlated with disease activity scores (r= 0.92, P<
13 0.001 and r= 0.85, P< 0.001), tender joint counts (r= 0.83, P< 0.001 and r= 0.82, P< 0.001 ), swollen
14 joint counts (r= 0.72, P< 0.001 and r= 0.60, P< 0.001), visual analogue scores (r=0.82, P< 0.001 and r=
15 0.82, P< 0.001), erythrocyte sedimentation rate (r= 0.75, P