Staff Members - Benha University
Serum Cystatin C and βeta2 Microglobulin as potential biomarkers in children with lupus nephritis
Archives of Rheumatology • 2021
Publication Information
Authors
Gehan Elolemy1, Nashwa Hashad1, Eman Baraka1
Keywords
Not Available
Journal
Archives of Rheumatology
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
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Supplementary Materials
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Abstract
Abstract
Objective: We aimed to assess serum levels of Cystatin C (Cys C) and βeta2 Microglobulin (β2M)
in juvenile systemic lupus erythematosus (JSLE) patients and investigate their role as potential
biomarkers of lupus nephritis (LN) and overall disease activity. Materials and Methods: Serum
(s) Cys C and β2M levels in 40 JSLE patients were compared to 40 matched controls. SLE Disease
Activity Index (SLEDAI-2K), the renal SLEDAI (rSLEDAI) and the renal damage index were
assessed. Results: JSLE patients had significantly elevated sCyc C and sβ2M levels (1.38 ± 0.78
mg/ml and 2.79 ±0.87 mg/ml) as compared to the controls (0.62 ± 0.12 mg/ml and 2.02 ± 0.18
mg/ml, respectively), P
Objective: We aimed to assess serum levels of Cystatin C (Cys C) and βeta2 Microglobulin (β2M)
in juvenile systemic lupus erythematosus (JSLE) patients and investigate their role as potential
biomarkers of lupus nephritis (LN) and overall disease activity. Materials and Methods: Serum
(s) Cys C and β2M levels in 40 JSLE patients were compared to 40 matched controls. SLE Disease
Activity Index (SLEDAI-2K), the renal SLEDAI (rSLEDAI) and the renal damage index were
assessed. Results: JSLE patients had significantly elevated sCyc C and sβ2M levels (1.38 ± 0.78
mg/ml and 2.79 ±0.87 mg/ml) as compared to the controls (0.62 ± 0.12 mg/ml and 2.02 ± 0.18
mg/ml, respectively), P