| publication name | Diagnostic Value of Anti-Mutated Citrullinated Vimentin versus Anti- Keratin Anti-bodies In early Diagnosis of Rheumatoid Arthritis |
|---|---|
| Authors | Ahmed S. Osman1, Somaya M. Desouky1,Mohammed D. Abdel Fattah1, Eman A. Baraka2 and Amira E. Ramadan1. |
| year | 2016 |
| keywords | |
| journal | The Egyptian journal of Medical Microbiology |
| volume | Not Available |
| issue | Not Available |
| pages | Not Available |
| publisher | Not Available |
| Local/International | Local |
| Paper Link | Not Available |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease that is associated with many auto-antibodies such as rheumatoid factor (RF), Antiperinuclear factor (APF) , anticitrullinated peptides and antikeratin antibodies (AKA). Objectives:This study aimed to measure the serum level of antimutated citrullinated vimentin antibodies(anti-MCV) and detection of AKA in serum of RA patients.Also,for comparison between the results of anti-MCV and AKA in diagnosis of early RA and their correlation with disease activity. Methodology: This study included 30 patients with RA ,30 patients with other rheumatic diseases and 30 matching healthy controls. Patient’s assessment measures involved the disease activity score (DAS-28) and visual analogue scale (VAS) . serum samples were collected from patients and controls for measurement of anti-MCV and detection of AKA using enzyme linked immunosorbant assay (ELISA) and indirect immunofluorescent (IIF)) technique respectively. Results: anti-MCV and AKA were significantly higher in patients compared to controls (p