Staff Members - Benha University
Diagnostic Value of Anti-Mutated Citrullinated Vimentin versus Anti- Keratin Anti-bodies In early Diagnosis of Rheumatoid Arthritis
The Egyptian journal of Medical Microbiology • 2016
Publication Information
Authors
Ahmed S. Osman1, Somaya M. Desouky1,Mohammed D. Abdel Fattah1, Eman
A. Baraka2 and Amira E. Ramadan1.
Keywords
Not Available
Journal
The Egyptian journal of Medical Microbiology
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
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publication.type
Local
Paper Link
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Supplementary Materials
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Abstract
Background: Rheumatoid arthritis (RA) is a chronic autoimmune
disease that is associated with many auto-antibodies such as
rheumatoid factor (RF), Antiperinuclear factor (APF) , anticitrullinated
peptides and antikeratin antibodies (AKA).
Objectives:This study aimed to measure the serum level of antimutated
citrullinated vimentin antibodies(anti-MCV) and detection of
AKA in serum of RA patients.Also,for comparison between the results
of anti-MCV and AKA in diagnosis of early RA and their correlation
with disease activity. Methodology: This study included 30 patients
with RA ,30 patients with other rheumatic diseases and 30 matching
healthy controls. Patient’s assessment measures involved the disease
activity score (DAS-28) and visual analogue scale (VAS) . serum
samples were collected from patients and controls for measurement of
anti-MCV and detection of AKA using enzyme linked immunosorbant
assay (ELISA) and indirect immunofluorescent (IIF)) technique
respectively. Results: anti-MCV and AKA were significantly higher in
patients compared to controls (p
disease that is associated with many auto-antibodies such as
rheumatoid factor (RF), Antiperinuclear factor (APF) , anticitrullinated
peptides and antikeratin antibodies (AKA).
Objectives:This study aimed to measure the serum level of antimutated
citrullinated vimentin antibodies(anti-MCV) and detection of
AKA in serum of RA patients.Also,for comparison between the results
of anti-MCV and AKA in diagnosis of early RA and their correlation
with disease activity. Methodology: This study included 30 patients
with RA ,30 patients with other rheumatic diseases and 30 matching
healthy controls. Patient’s assessment measures involved the disease
activity score (DAS-28) and visual analogue scale (VAS) . serum
samples were collected from patients and controls for measurement of
anti-MCV and detection of AKA using enzyme linked immunosorbant
assay (ELISA) and indirect immunofluorescent (IIF)) technique
respectively. Results: anti-MCV and AKA were significantly higher in
patients compared to controls (p