Vitiligo is a chronic pigmentary skin disease.Vitiligo patients suffer from low self-esteem and poor body image which may cause a lower level of quality of life. The aim of this study was to assess the impairment of quality of life in adults with vitiligo compared with unaffected controls. Subjects and Methods: A case-control study was conducted at Benha University Hospital, Benha City, Qalubia governorate; Egypt. The study group comprised 95 cases with vitiligo and 100 unaffected controls. All participants were interviewed using the Dermatology Life Quality Index (DLQI) questionnaire. Results: The total mean DLQI score in vitiligo was 12.3, compared with 3.02 in healthy controls (p < 0.001). In vitiligo, females experienced a greater impact on Quality of Life than males. Conclusion and Recommendations: patients with vitiligo are prone to have a lower level of quality of life, so management should contain both medical treatment and psychological interventions.