Background: Osteoporosis is a highly prevalent disease particularly in postmenopausal women, characterized by decreased bone density resulting in increased susceptibility to fracture. Osteoporosis causes increased morbidity, mortality, physical impairment and loss of functional ability that have a bad impact on patients’ Quality of Life (QoL).
Objectives: Identification of females at risk of osteoporosis among workers at Benha Faculty of Medicine and University Hospital, prediction of the ten years probability of fracture and assessment of their (QoL).

Methods: It was a cross- sectional study conducted on 250 females aging (40 -60 years). Osteoporosis Self Assessment Tool "OST” which is a prescreening test was used to identify population at risk of osteoporosis. FRAX ® questionnaire was used for prediction of the ten years probability of the major and hip fractures .Finally, (QoL) of the at risk group was assessed using Osteoporosis Targeted Quality of Life (OPTQoL) questionnaire.

Results: OST classified the studied group into no risk group "71.2%" and at risk group "28.8%" (among the at risk group, 33.3% belonged to low risk category while 66.7% were at moderate risk). Old age, low body weight, low BMI and short stature were significant risk factors for osteoporosis. Also, lack of regular sunlight exposure, thyroid hormone intake, early menopause and lack of milk and yoghurt intake were significant risk factors. There were significant differences between the two groups as regards major and hip fractures and total score of (QoL) (P value