Staff Members - Benha University
Possible healing effects of Salvadora persica extract (MISWAK) and laser therapy in a rabbit model of a caustic‑induced tongue ulcers: histological, immunohistochemical and biochemical study
• 2020
Publication Information
Authors
Eman Mohamed Faruk1 · Ola Elsayed Nafea2 · Hanan Fouad3 · Usama Fouad Ahmed Ebrahim4 ·
Rehab Abd Allah Hasan5
Keywords
Acetic acid · Caustics · Histo-morphometry · Laser · Salvadora persica · Tongue ulcers
Journal
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Publisher
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Volume
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Issue
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Pages
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publication.type
Local
Paper Link
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Supplementary Materials
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Abstract
Caustic ingestion is a potentially detrimental event that can cause serious devastating damage on contact with tissues. Local
exposure is associated with severe pain, swelling and ulceration. Caustics-induced oral ulcers can be painful enough to
compromise the patient’s quality of life. Treatment of oral ulcers is crucial in clinical practice. Albeit, some ulcers do not
respond adequately to the conventional treatment. The current study was conducted to evaluate the potential healing effects
of topical Salvadora persica (SP) extract, low-level laser (LLL) and high-level laser (HLL) therapies in a rabbit model of
caustic-induced tongue ulcers and explore the underlying mechanisms. Fifty male rabbits with a caustic induced tongue
ulcers were included in the study. Rabbits were equally divided into four groups: positive control (ulcer) group, SP, LLL
and HLL groups in addition to the negative control (healthy) group. All treatments were given thrice weekly for 14 days.
Results showed that acetic acid-induced tongue ulcers caused extensive structural tongue damage secondary to overexpression
of apoptotic BAX, pathological angiogenesis indicated by VEGF overexpression, marked collagen fibers deposition
as well as upregulation of tissue pro-inflammatory TNF-α and upregulation of tissue anti-inflammatory IL-10. The healing
potential of topical SP, LLL and HLL therapy are mostly comparable. In conclusion, acetic acid-induced extensive tongue
damage. Topical SP extract, LLL and HLL are equally effective therapies against caustics-induced tongue ulcers. However,
we recommend SP extract, owing to its safety, non-invasiveness, availability and low cost.
exposure is associated with severe pain, swelling and ulceration. Caustics-induced oral ulcers can be painful enough to
compromise the patient’s quality of life. Treatment of oral ulcers is crucial in clinical practice. Albeit, some ulcers do not
respond adequately to the conventional treatment. The current study was conducted to evaluate the potential healing effects
of topical Salvadora persica (SP) extract, low-level laser (LLL) and high-level laser (HLL) therapies in a rabbit model of
caustic-induced tongue ulcers and explore the underlying mechanisms. Fifty male rabbits with a caustic induced tongue
ulcers were included in the study. Rabbits were equally divided into four groups: positive control (ulcer) group, SP, LLL
and HLL groups in addition to the negative control (healthy) group. All treatments were given thrice weekly for 14 days.
Results showed that acetic acid-induced tongue ulcers caused extensive structural tongue damage secondary to overexpression
of apoptotic BAX, pathological angiogenesis indicated by VEGF overexpression, marked collagen fibers deposition
as well as upregulation of tissue pro-inflammatory TNF-α and upregulation of tissue anti-inflammatory IL-10. The healing
potential of topical SP, LLL and HLL therapy are mostly comparable. In conclusion, acetic acid-induced extensive tongue
damage. Topical SP extract, LLL and HLL are equally effective therapies against caustics-induced tongue ulcers. However,
we recommend SP extract, owing to its safety, non-invasiveness, availability and low cost.