Staff Members - Benha University
Role of Serum Hepcidin Level in Predicting Anemia and Cardiovascular Morbidity in Children with Chronic Kidney Disease.
• 2022
Publication Information
Authors
Eman Abdelbaset M Sarhan1, Abd-El Hameed Abd El Monem Abd El Hameed1,
Soha A Ebraheim1, Eman R Abdelgawad2, Eman G Abdelrahman1.
Keywords
Not Available
Journal
Not Available
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Introduction: The risk of mortality for pediatric patients with severe chronic kidney disease (CKD) is 30-
fold higher than that for healthy patients of the same age. The main cause of death is cardiovascular disease
(CVD), accounting for 25–50 % of deaths in children and young adults with childhood onset CKD.
Aim of the study: To study serum hepcidin level and its role in anemia and cardiovascular dysfunction
in children with CKD, either on hemodialysis (HD) or on conservative therapy.
Methods: Serum samples were obtained from 20 healthy individuals and from 30 patients with CKD on
regular dialysis (group I) and 20 patients with chronic kidney diseases on conservative therapy (group
II).The levels of hemoglobin , serum ferritin, s. iron , TIBC, serum hepcidin, and echo parameters in form
of fractional shortening (FS),l eft ventricular mass index (LVMI) and trans mitral to mitral annular early
diastolic velocity ratio (E/Ea’) ratio were determined and the correlation between them was studied.
Results: There is a significant increase in the serum hepcidin levels in group I and group II than the control
group. There was significant correlation between hepcidin and serum ferritin, s. iron, transferrin saturation,
FS, LVMI, E/Ea’ while there was a negative correlation between serum hepcidin and both hemoglobin
and TIBC.
Conclusion: Hepcidin level is a good biomarker for anemia and cardiac dysfunction in patients with
chronic kidney disease.
fold higher than that for healthy patients of the same age. The main cause of death is cardiovascular disease
(CVD), accounting for 25–50 % of deaths in children and young adults with childhood onset CKD.
Aim of the study: To study serum hepcidin level and its role in anemia and cardiovascular dysfunction
in children with CKD, either on hemodialysis (HD) or on conservative therapy.
Methods: Serum samples were obtained from 20 healthy individuals and from 30 patients with CKD on
regular dialysis (group I) and 20 patients with chronic kidney diseases on conservative therapy (group
II).The levels of hemoglobin , serum ferritin, s. iron , TIBC, serum hepcidin, and echo parameters in form
of fractional shortening (FS),l eft ventricular mass index (LVMI) and trans mitral to mitral annular early
diastolic velocity ratio (E/Ea’) ratio were determined and the correlation between them was studied.
Results: There is a significant increase in the serum hepcidin levels in group I and group II than the control
group. There was significant correlation between hepcidin and serum ferritin, s. iron, transferrin saturation,
FS, LVMI, E/Ea’ while there was a negative correlation between serum hepcidin and both hemoglobin
and TIBC.
Conclusion: Hepcidin level is a good biomarker for anemia and cardiac dysfunction in patients with
chronic kidney disease.