A series of β-Oxoalkanenitriles disperse dyes were synthesized. The structures of all dyes were established by elemental analysis and spectral studies (IR, 1H-NMR, MS). These dyes were applied to polyester fabrics as disperse dyes by using conventional dyeing method. Fabrics dyed with the dyes under study furnished generally deep and bright intense hues ranging from light yellow to orange. Fastness properties of dyed polyester samples were measured and the position of color in CIELAB coordinates (L*, a*, b*, H*, C*) was assessed. Finally, the antibacterial activity of the synthesized dyes and dyed samples was also evaluated qualitatively according to AATCC test method (147-1988).