A total number of 27 mature Ossimi ewes divided into three groups (9 ewes/each). The 1
st group, which
served as control (C), was treated with distilled water (10 mL/kg B.W. /day), the 2nd group treated with
selenium nanoparticles (SeNPs 1 mg/kg B.W. /day), and the 3rd group treated with L-Carnitine (L-Car 350
mg/Kg/day). Data revealed that the hematological parameters hematocrit (HCt) had significant differences (at
90 days of pregnancy, P = 0.0299) and mean cell volume (MCV) showed significant differences (at days 45
and 90, P = 0.0014 and P = 0.0580, respectively). Triglyceride (TG) levels changed significantly at 45, 90, and
150 days of pregnancy; total cholesterol levels changed significantly at 150 days; low-density lipoprotein (LDL)
levels changed at 45 and 90 days of pregnancy; and high-density lipoprotein (HDL) levels changed at 45 and 90
days of pregnancy. AST and ALT decreased due to the treatment with SeNPs and L-Carnitine (L-Car) during
45, 90, and 150 days of pregnancy, while ALT decreased during 90 and 150 days of pregnancy due to the
treatment with SeNPs and L-Car compared with the control group. The urea concentration showed a significant
decrease due to the treatments during 90, and 150 days of pregnancy, and the creatinine concentration
significantly decreased at 90 days of pregnancy. Furthermore, data showed significant decreases in oxidized
glutathione (at days 90 and 150, P = 0.0001) and nitric oxide (at days 45 and 150) due to the treatment with
SeNPs and L-Car. It was found that there was a significant improvement in blood serum ATP and an increase in
reduced glutathione and superoxide dismutase due to LC and SeNPs treatment during different pregnancy
periods. Hence, SeNPs and L-Car administration improved different biochemical and hematological parameters
and serum antioxidant activities for Ossimi ewes during different periods of pregnancy