Staff Members - Benha University
Role of speckle tracking in the evaluation of left ventricular remodeling after streptokinase infusion in patients with acute anterior myocardial infarction
Rational Pharmacotherapy in Cardiology • 2020
Publication Information
Authors
Shereen Ibrahim Farag; Khaled Emad El-Din El-Rabbat; Mohamed Ali El-Awadi; AL-Shimaa Mohamed Sabry
Keywords
ST-segment elevation myocardial infarction; speckle-tracking; ventricular remodeling
Journal
Rational Pharmacotherapy in Cardiology
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
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Abstract
Background: left ventricular (LV) remodeling is an adverse consequence after acute myocardial infarction
Objective: to assess the role of speckle tracking in the evaluation of LV remodeling after streptokinase infusion in patients with acute anterior ST-segment elevation myocardial infarction (STEMI).
Patients and methods: A total of 200 patients with first acute anterior STEMI received streptokinase as a reperfusion therapy were included. Conventional echocardiography and speckle tracking were performed within 3 days of admission and 3 months later. According to the development of LV remodeling, patients were classified into two groups. Group (I) patients with LV remodeling (60 patients) and group (II) patients without remodeling (140 patients).
Results: Patients with LV remodeling had lower global longitudinal (GLS) and circumferential (GCS) strain values (-13.19 ± 4.57 vs. -18.90 ±4.23 % and -13.16 ± 4.27 vs. -17.16 ± 3.3 %, respectively, P -13.5 was shown to have the best diagnostic accuracy (sensitivity = 60.0% & specificity = 87.1%) in predicting LV remodeling [AUC 0.816, 95% CIs 0.754 - 0.877, P < 0.001]. GCS cutoff value of > -16.21 was shown to have the best diagnostic accuracy (sensitivity = 75.0% & specificity = 71.4%) in predicting LV remodeling [AUC 0.785, 95% CIs 0.719 - 0.85, P < 0.001].
Conclusion: Speckle tracking echocardiography either longitudinal or circumferential strain has good sensitivity and specificity in predicting LV remodeling after acute myocardial infarction.
Objective: to assess the role of speckle tracking in the evaluation of LV remodeling after streptokinase infusion in patients with acute anterior ST-segment elevation myocardial infarction (STEMI).
Patients and methods: A total of 200 patients with first acute anterior STEMI received streptokinase as a reperfusion therapy were included. Conventional echocardiography and speckle tracking were performed within 3 days of admission and 3 months later. According to the development of LV remodeling, patients were classified into two groups. Group (I) patients with LV remodeling (60 patients) and group (II) patients without remodeling (140 patients).
Results: Patients with LV remodeling had lower global longitudinal (GLS) and circumferential (GCS) strain values (-13.19 ± 4.57 vs. -18.90 ±4.23 % and -13.16 ± 4.27 vs. -17.16 ± 3.3 %, respectively, P -13.5 was shown to have the best diagnostic accuracy (sensitivity = 60.0% & specificity = 87.1%) in predicting LV remodeling [AUC 0.816, 95% CIs 0.754 - 0.877, P < 0.001]. GCS cutoff value of > -16.21 was shown to have the best diagnostic accuracy (sensitivity = 75.0% & specificity = 71.4%) in predicting LV remodeling [AUC 0.785, 95% CIs 0.719 - 0.85, P < 0.001].
Conclusion: Speckle tracking echocardiography either longitudinal or circumferential strain has good sensitivity and specificity in predicting LV remodeling after acute myocardial infarction.