Background: left ventricular (LV) remodeling is an adverse consequence after acute myocardial infarction Objective: to assess the role of speckle tracking in the evaluation of LV remodeling after streptokinase infusion in patients with acute anterior ST-segment elevation myocardial infarction (STEMI). Patients and methods: A total of 200 patients with first acute anterior STEMI received streptokinase as a reperfusion therapy were included. Conventional echocardiography and speckle tracking were performed within 3 days of admission and 3 months later. According to the development of LV remodeling, patients were classified into two groups. Group (I) patients with LV remodeling (60 patients) and group (II) patients without remodeling (140 patients). Results: Patients with LV remodeling had lower global longitudinal (GLS) and circumferential (GCS) strain values (-13.19 ± 4.57 vs. -18.90 ±4.23 % and -13.16 ± 4.27 vs. -17.16 ± 3.3 %, respectively, P -13.5 was shown to have the best diagnostic accuracy (sensitivity = 60.0% & specificity = 87.1%) in predicting LV remodeling [AUC 0.816, 95% CIs 0.754 - 0.877, P < 0.001]. GCS cutoff value of > -16.21 was shown to have the best diagnostic accuracy (sensitivity = 75.0% & specificity = 71.4%) in predicting LV remodeling [AUC 0.785, 95% CIs 0.719 - 0.85, P < 0.001]. Conclusion: Speckle tracking echocardiography either longitudinal or circumferential strain has good sensitivity and specificity in predicting LV remodeling after acute myocardial infarction.