The Spodoptera furgipedra SF9 cell line was tested by B-Phenylpyruvic acid, Hematoporphyrin IX, L-tryptophan, Mandelic acid, Histidine and L-b-phenyllactic acid for comparing the photodynamic effect. After irradiation of the tested cells, the photodynamic effect was measured with MTT assay. The results indicated that the B-phenylpyruvic acid and Hematoporphyrin IX were the most effective photoinsecticides than the others. The L-tryptophan, Mandelic acid, Histidine and L-b-phenyllactic acids were found to have a weak photodynamic effect. So we can conclude that both B-phenylpyruvic acid and Hematoporphyrin IX were more acceptable to be used as a photoinsecticide against S. furgipedra.