Staff Members - Benha University
Current Use of Adenovirus Vectors and Their Production Methods
• 2019
Publication Information
Authors
Ekramy E. Sayedahmed, Rashmi Kumari, and Suresh K. Mittal
Keywords
Adenovirus vector, Gene delivery system, Gene therapy, Vector design, Vector production, Recombinant vaccines
Journal
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Publisher
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Volume
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Issue
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Pages
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publication.type
Local
Paper Link
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Supplementary Materials
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Abstract
Various adenovirus (AdV) vector systems have proven to be lucrative options for gene delivery. They can
serve as potential vaccine candidates for prevention of several common infectious diseases and hold the
promise for gene therapy, especially for cancer. Several AdV vector-based therapies are currently at various
stages of clinical trials worldwide, which make an immense interest of both the clinicians and researchers.
Since these vectors are easy to manipulate, have broad tropism, and have the capability to yield high titers,
this delivery system has a wide range of applications for different clinical settings. This chapter emphasizes
on some of the current usages of AdV vectors and their production methods.
serve as potential vaccine candidates for prevention of several common infectious diseases and hold the
promise for gene therapy, especially for cancer. Several AdV vector-based therapies are currently at various
stages of clinical trials worldwide, which make an immense interest of both the clinicians and researchers.
Since these vectors are easy to manipulate, have broad tropism, and have the capability to yield high titers,
this delivery system has a wide range of applications for different clinical settings. This chapter emphasizes
on some of the current usages of AdV vectors and their production methods.