Objectives:- To assess the efficiency of different forms of zinc supplementation in comparison to ORS without zinc in treatment of acute diarrhea in children. Back ground:- Case control study of cases admitted at pediatric departmentat Benha Fever Hospital. Patient and methods:- This study was done on 100 of infant/ children with acute diarrhea aged 4- 48 months it divided into two groups, Study group which subdivided into two subgroups:group (1): 40 infants/children received zinc syrup (sulfozinc),group (2):40 infants/children received ORS with zinc(Rehydro- zinc sachets),.Control group(group(3): 20 infants/children received ORS (Hydrosafe sachets). Results:- Frequency of diarrhea significant low in study group vs control group(3± 0.47,3.4± 0.63vs5 ± 0.79) also duration of diarrhea significant low in study group in vs control group( 3.3 ±0.52,3.6 ± 0.49 vs 5 ± 0.6). Conclusion:- Supplementation of zinc useful for treatment acute diarrhea as it reduce duration , frequency of diarrhea in children /infant with acute diarrhea.