Background: Jaundice is an important problem in the first week of life. It is a cause of concern for the physician and a source of anxiety for the parents. Fibrates can increase bilirubin conjugation and excretion via induction of glucuronyltransferase activity. Methods: Forty full term neonates admitted to the "N.I.C.U." of Benha Children Hospital suffering from neonatal indirect hyperbilirubinemia. Twenty neonates received fenofibrate (10 mg/kg) as adjuvant therapy in addition to phototherapy while the other twenty neonates received phototherapy alone. Results: we found that neonates treated with fenofibrate and phototherapy had 5.3 mean NICU stay which is shorter than NICU stay of neonates treated with phototherapy alone whose admission duration mean was 5.8 . Conclusion:Our study revealed that use of fenofibrate in addition to phototherapy has additional benefit regarding time of stay and rate of bilirubin reduction in comparison to treatment with phototherapy alone.